Articles by Dr. Erdman are for informational purposes, and are not to be taken as specific medical advice.
There has been a dramatic rise in cardiovascular disease in
this country. Arterial hardening or the loss of elasticity of the artery wall
is a leading cause of heart attack deaths, coronary artery disease, and stroke.
Dr. Kilmer McCully originally reported in 1969 that elevated
homocysteine levels were associated with advanced atherosclerosis (plaquing) of
the arteries and premature death. He based the findings on a study of children
born with a genetic disorder called homocystinuria. These patients had
genetically induced super high levels of homocysteine, and they often died at
very young ages with advanced hardening of the arteries.
Homocysteine is an inflammatory amino acid that is produced
as a byproduct of metabolism of the protein methionine. During metabolism of
methionine, significant levels of B6, B12, folate, B2
and magnesium must be present in order to be synthesized properly into
glutathione. Glutathione is a powerful antioxidant that protects against
oxidative stress.