Articles by Dr. Erdman are for informational purposes, and are not to be taken as specific medical advice.
Lyme disease is a difficult condition to diagnose. Testing
is often ordered incorrectly, or the tests ordered are not the best available.
Most commercial tests designed to detect chronic infections
are based on measuring your body’s immune reaction (the presence of antibodies)
to the microbe. The problem with Lyme is that the primary cells it infects are
white blood cells themselves. Why is this a problem? Because if white blood
cells are infected, they lose the ability to produce antibodies, which is what
the tests are looking for. This is a false negative test result.
There are direct blood tests for the co-infections
associated with Lyme, such as Babesia. But, the blood tests have difficulties
too. For example, the FISH test for Babesia is done on blood, but it lives
primarily in the central nervous system, joints and connective tissue. It
doesn’t live in the blood stream, at least in significant amounts, so it is
easily missed when looking in the blood.